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The atypical antipsychotics (AAP), also known as second generation antipsychotics (SGAs) and serotonin–dopamine antagonists (SDAs), [1] [2] are a group of antipsychotic drugs (antipsychotic drugs in general are also known as tranquilizers and neuroleptics, although the latter is usually reserved for the typical antipsychotics) largely introduced after the 1970s and used to treat psychiatric ...
The difference between first- and second-generation antipsychotics is a subject of debate. The second-generation antipsychotics are generally distinguishable by the presence of 5HT2A receptor antagonism and a corresponding lower propensity for extrapyramidal side effects compared to first-generation antipsychotics. [15]
Bottle containing capsules of loxapine, a mid-potency typical antipsychotic. Typical antipsychotics (also known as major tranquilizers, and first generation antipsychotics) are a class of antipsychotic drugs first developed in the 1950s and used to treat psychosis (in particular, schizophrenia). Typical antipsychotics may also be used for the ...
Antipsychotics by class Generic name Brand names Chemical class ATC code Typical antipsychotics; Acepromazine: Atravet, Acezine: phenothiazine: N05AA04
4.1 Atypical antipsychotics. 5 Bipolar Disorder. Toggle Bipolar Disorder subsection. ... 8.1.3 High potency. 8.2 Atypical Antipsychotics. 8.3 Adjuncts. 9 See also. 10 ...
Quetiapine binds D 1, D 2 and D 3 and can bind D 4 at high concentrations. [2] It is used to treat the positive symptoms of schizophrenia, [13] bipolar disorder and depression. [1] Of the second generation antipsychotics, quetiapine may produce fewer parkinsonian side effects. [24] Paliperidone binds D 2, D 3 and D 4 with high affinity; can ...