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Transcriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene. [ 5 ] [ 6 ] CTCF is involved in many cellular processes, including transcriptional regulation , insulator activity, V(D)J recombination [ 7 ] and regulation of chromatin architecture.
The protein CTCF is involved in repressing expression of the gene, by binding to the H19 imprinting control region (ICR) along with Differentially-methylated Region-1 (DMR1) and Matrix Attachment Region −3 (MAR3). These three DNA sequences bind to CTCF in a way that limits downstream enhancer access to the IGF2 region. The mechanism in which ...
CTCF forms methylation-sensitive insulators that regulate X-chromosome inactivation. Transcriptional repressor CTCFL (this protein) is a paralog of CTCF and appears to be expressed primarily in the cytoplasm of spermatocytes, unlike CTCF which is expressed primarily in the nucleus of somatic cells. CTCF and CTCFL are normally expressed in a ...
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[[Category:Genetics templates]] to the <includeonly> section at the bottom of that page. Otherwise, add <noinclude>[[Category:Genetics templates]]</noinclude> to the end of the template code, making sure it starts on the same line as the code's last character.
This Wikipedia page has been superseded by template:diagnostic_testing_diagram and is retained primarily for historical reference. True condition: Total population:
{}, a similar template that generates the direct link using the gene ID number {{ Yeast Gene }} , a similar template for the Yeast Genome Database . {{ GeneCard }} , a similar template for the GeneCards database .