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Trazodone is usually used at a dosage of 150 to 300 mg/day for the treatment of depression. [ 17 ] [ 13 ] Lower doses have also been used to augment other antidepressants or when initiating therapy. [ 17 ] [ 13 ] Higher doses, up to 600 mg/day, have been used in more severe cases of depression (in hospitalized patients, for example). [ 29 ]
This is a list of adverse effects of the antidepressant trazodone, ... Insomnia; Dream disorder; ... Rare (<0.1%) adverse effects include: Urinary retention;
Niaprazine (Nopron) – a drug related to this group but does not inhibit the reuptake of serotonin or the other monoamines. Medifoxamine (Clédial, Gerdaxyl) – could perhaps technically be said to belong to this group, as it is a serotonin–dopamine reuptake inhibitor and 5-HT 2A and 5-HT 2C receptor antagonist, but not grouped as such. [1]
The rate of dosage reduction is best carried out so as to minimize the symptoms' intensity and severity. Anecdotally, a slow rate of reduction may reduce the risk of developing a severe protracted syndrome. Long half-life benzodiazepines like diazepam [1] or chlordiazepoxide are preferred to minimize rebound effects and are available in low ...
A postulated "spectrum concept" of serotonin toxicity emphasises the role that progressively increasing serotonin levels play in mediating the clinical picture as side effects merge into toxicity. The dose-response relationship is the effect of progressive elevation of serotonin, either by raising the dose of one drug, or combining it with ...
The side effects of the TCAs usually come to prominence before the therapeutic benefits against depression and/or anxiety do, and for this reason, they may potentially be somewhat dangerous, as volition can be increased, possibly giving the patient a greater desire to attempt or commit suicide.
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