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  2. Extracellular matrix - Wikipedia

    en.wikipedia.org/wiki/Extracellular_matrix

    In biology, the extracellular matrix (ECM), [1] [2] also called intercellular matrix (ICM), is a network consisting of extracellular macromolecules and minerals, such as collagen, enzymes, glycoproteins and hydroxyapatite that provide structural and biochemical support to surrounding cells.

  3. Chondrocyte - Wikipedia

    en.wikipedia.org/wiki/Chondrocyte

    The G380R mutation causes FGFR-3 to over express FGFs and the balance within the cartilage extracellular matrix is thrown off. Chondrocytes will proliferate too quickly and disrupt the assembly at the cartilage anlage and detrimentally alter the formation of bone.

  4. Cartilage - Wikipedia

    en.wikipedia.org/wiki/Cartilage

    Cartilage growth thus refers to the matrix deposition, but can also refer to both the growth and remodeling of the extracellular matrix. Due to the great stress on the patellofemoral joint during resisted knee extension, the articular cartilage of the patella is among the thickest in the human body.

  5. Why are older women predisposed to osteoarthritis?

    www.aol.com/why-older-women-predisposed...

    One recent study in mice uncovered that menopause led to a drop in 17beta-estradiol and progesterone, which increased cartilage aging, degeneration, and disassembly of the extracellular matrix.

  6. Hyaline cartilage - Wikipedia

    en.wikipedia.org/wiki/Hyaline_cartilage

    The articular cartilage extracellular matrix has a highly specialized architecture that is zonally organized: the superficial zone consists mostly of type II collagen fibers aligned parallel to the articular surface to resist shear forces, whereas the deep zone consists of the same fibers aligned perpendicularly to the bone interface to absorb ...

  7. Matrilin-3 - Wikipedia

    en.wikipedia.org/wiki/Matrilin-3

    Matrilin-3 is a protein that in humans is encoded by the MATN3 gene. [5] [6] [7] It is linked to the development of many types of cartilage, [8] and part of the Matrilin family, which includes Matrilin-1, Matrilin-2, Matrilin-3, and Matrilin-4, a family of filamentous-forming adapter oligomeric extracellular proteins that are linked to the formation of cartilage and bone, as well as ...

  8. Chondroblast - Wikipedia

    en.wikipedia.org/wiki/Chondroblast

    The extracellular matrix secreted by chondroblasts is composed of fibers, collagen, hyaluronic acid, proteoglycans, glycoproteins, water, and a host of macromolecules. Within finished cartilage, collagen fibers compose 10-20% of the volume, water 65-80%, and the proteoglycan-hyaluronic acid aggregates the remaining portion.

  9. Cartilage oligomeric matrix protein - Wikipedia

    en.wikipedia.org/wiki/Cartilage_oligomeric...

    The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. [8] It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfide bonds. Binding to other ECM proteins such as ...