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There is little modern clinical research on Dioscorea villosa, and the one study of a wild yam-containing cream for menopausal symptoms failed to find any value from this therapy. [18] According to the American Cancer Society, there is no evidence to support wild yam or diosgenin being either safe or effective in humans. [19]
The natural, plant-derived progesterone creams sold over the counter contain too little progesterone to be effective. Wild yam (Dioscorea villosa) extract creams are not effective since the natural progesterone present in the extract is not bioavailable. [27]
Women often use hormone therapy to relieve hot flashes and other menopause symptoms — and new research suggests patches or creams may be safer for their blood pressure than pills. High blood ...
Creams. Conjugated estrogens (Premarin) – 0.625 mg/g (0.0625%) ... For Women: Menopause—Medicines to Help You – U.S. Food and Drug Administration
Creams are often marketed with such language, Barbieri says, adding that they may contain a version of progesterone made in a lab using a compound in yams, she says.
Progesterone is used as part of hormone replacement therapy in people who have low progesterone levels, and for other reasons. For purposes of comparison with normal physiological circumstances, luteal phase levels of progesterone are 4 to 30 ng/mL, while follicular phase levels of progesterone are 0.02 to 0.9 ng/mL, menopausal levels are 0.03 to 0.3 ng/mL, and levels of progesterone in men ...