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A deuterated drug is a small molecule medicinal product in which one or more of the hydrogen atoms in the drug molecule have been replaced by its heavier stable isotope deuterium. Because of the kinetic isotope effect, deuterium-containing drugs may have significantly lower rates of metabolism, and hence a longer half-life. [1] [2] [3]
Over a hundred of the 224 drugs mentioned in the Huangdi Neijing – an early Chinese medical text – are herbs. [11] Herbs also commonly featured in the medicine of ancient India, where the principal treatment for diseases was diet. [12] A sample of raw opium. Opioids are among the world's oldest known drugs.
It also maintains List I of chemicals and List II of chemicals, which contain chemicals that are used to manufacture the controlled substances/illicit drugs. The list is designated within the Controlled Substances Act [ 1 ] but can be modified by the U.S. Attorney General as illegal manufacturing practices change.
In 2023 Pironon and de Donato announced the discovery of a deposit they estimated to be some 46 million to 260 million metric tons (several years worth of 2020s production). [18] In 2024, a natural deposit of helium and hydrogen was discovered in Rukwa, Tanzania., [19] as well in Bulqizë, Albania. [20]
A deuterated drug is a small molecule medicinal product in which one or more of the hydrogen atoms in the drug molecule have been replaced by deuterium. Because of the kinetic isotope effect , deuterium-containing drugs may have significantly lower rates of metabolism , and hence a longer half-life .
Many drugs have more than one name and, therefore, the same drug may be listed more than once. Brand names and generic names are differentiated by capitalizing brand names. See also the list of the top 100 bestselling branded drugs , ranked by sales.
Drug precursors, also referred to as precursor chemicals or simply precursors, are substances used to manufacture illicit drugs. Most precursors also have legitimate commercial uses and are legally used in a wide variety of industrial processes and consumer products, such as medicines, flavourings, and fragrances.
INCB "Yellow list" – List of Narcotic Drugs under International Control [5] Chemical Weapons Convention, 1997; UN Convention on Drug Precursor Chemicals [6] INCB "Red list" – List of Chemicals frequently used in the Illicit Manufacture of Narcotic Drugs and Psychotropic Substances under International Control [7]