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Alpha-1 agonists are a class of medications used in the management of many disorders, including vasodilatory shock, hypotension, hypoperfusion, septic shock, cardiopulmonary arrest, heart failure decompensation, as well as other lower acuity conditions.
Alpha-adrenergic agonists are a class of sympathomimetic agents that selectively stimulates alpha adrenergic receptors. The alpha-adrenergic receptor has two subclasses α 1 and α 2 . Alpha 2 receptors are associated with sympatholytic properties.
Alpha1 adrenergic receptors are a type of adrenergic receptors that play a central role in the sympathetic nervous system—the part of the nervous system that increases heart rate, blood pressure, breathing rate, and eye pupil size.
The use of alpha-1 agonists is common in all types of shock, cardiopulmonary resuscitation, and heart failure decompensation. Alpha-1 agonists, such as phenylephrine, are also used to treat upper airway congestion as stimulating the receptor leads to a decreased mucus secretion.
alpha-1 (α 1) adrenergic receptors are G protein-coupled receptors (GPCRs) associated with the G q heterotrimeric G protein. α 1-adrenergic receptors are subdivided into three highly homologous subtypes, i.e., α 1A-, α 1B-, and α 1D-adrenergic receptor subtypes.
An alpha-2 adrenergic agonist used to treat hypertension and severe cancer pain, among other conditions, and to treat withdrawal symptoms from various substances. It is also used to aid in the diagnosis of pheochromocytoma and to prevent migraines.
Phenylephrine primarily acts as an alpha-1 adrenergic receptor agonist, exhibiting minimal to no beta-adrenergic activity. Consequently, the medication is an optimal choice for raising mean arterial pressure (MAP) by inducing vasoconstriction in both veins and arteries and enhancing cardiac preload without exerting significant effects on ...
Alpha-1 agonists are a class of medications used in the management of many disorders, including vasodilatory shock, hypotension, hypoperfusion, septic shock, cardiopulmonary arrest, heart failure decompensation, as well as other lower acuity conditions.
To understand the agonist specificity of α 1-AR, we solved cryo-EM structures of human α 1A-AR bound to A61603 (a synthetic specific agonist for α 1A-AR) at 2.6 Å or epinephrine (an...
Alpha-1 adrenergic receptors are present on vascular smooth muscle and myocardial tissue; therefore, stimulation causes vasoconstriction and positive inotropic effects, respectively. Higher acuity indications for alpha-1 receptor agonists include cases of vasodilatory shock, hypotension, and hypoperfusion. Often patients receiving an alpha-1 ...