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Antibiotic resistance—when bacteria change so antibiotics no longer work in people who need them to treat infections—is now a major threat to public health." [16] Each year, nearly 5 million deaths are associated with AMR globally. [7] In 2019, global deaths attributable to AMR numbered 1.27 million in 2019.
[12] [13] Leprosy has shown an increasing resistance to dapsone. A rapid process of sharing resistance exists among single-celled organisms, and is termed horizontal gene transfer in which there is a direct exchange of genes, particularly in the biofilm state. [14] A similar asexual method is used by fungi and is called "parasexuality".
It is a contributing factor to the development of antibiotic resistance, including the creation of multidrug-resistant bacteria, informally called "super bugs": relatively harmless bacteria (such as Staphylococcus, Enterococcus and Acinetobacter) can develop resistance to multiple antibiotics and cause life-threatening infections. [1]
Cubist Reinforces Its Global Commitment to Addressing Increasing Antibiotic Resistance at ICAAC 2013 LEXINGTON, Mass.--(BUSINESS WIRE)-- Cubist Pharmaceuticals, Inc. (NAS: CBST) today reinforced ...
With increased access to modern medicine there has been a sharp increase in the amount of antibiotics consumed. [3] Given the abundant use of antibiotics there has been a considerable increase in the evolution of antimicrobial resistance factors, now outpacing the development of new antibiotics. [4]
Efflux mechanisms to remove antibiotics [9] Increased mutation rate as a stress response [10] Many different bacteria now exhibit multi-drug resistance, including staphylococci, enterococci, gonococci, streptococci, salmonella, as well as numerous other Gram-negative bacteria and Mycobacterium tuberculosis.
Amoxicillin is an antibiotic that’s used to treat bacterial infections like pneumonia, bronchitis, and infections of the ears, nose, throat, urinary tract, and skin, according to Medline Plus ...
Other research has been devoted to finding antibiotic resistance breakers (ARB's) which enhance an antibiotic's potency. This effect is mediated through direct antibacterial activity of the ARB, targeting and destroying mechanisms of bacterial resistance thereby allowing the antibiotic to function properly, interacting with the host to trigger ...