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Adipose tissue (also known as body fat or simply fat) is a loose connective tissue composed mostly of adipocytes. [1] [2] It also contains the stromal vascular fraction (SVF) of cells including preadipocytes, fibroblasts, vascular endothelial cells and a variety of immune cells such as adipose tissue macrophages.
White adipose tissue or white fat is one of the two types of adipose tissue found in mammals. The other kind is brown adipose tissue. White adipose tissue is composed of monolocular adipocytes. In humans, the healthy amount of white adipose tissue varies with age, but composes between 6–25% of body weight in adult men and 14–35% in adult women.
The marrow adipose tissue depot is poorly understood in terms of its physiologic function and relevance to bone health. Marrow adipose tissue expands in states of low bone density but additionally expands in the setting of obesity. [4] Marrow adipose tissue response to exercise approximates that of white adipose tissue.
Notably, she authored a fundamental review on brown adipose tissue function in Physiological Reviews and a paradigm-changing review article for the American Journal of Physiology where she presented findings from radiology literature suggesting the existence of brown adipose tissue in adult humans. [7]
In the 1980s and 1990s, he established distinct signaling pathways and functional roles for adrenergic stimulation of brown adipose tissue [17] and showed that alpha1-adrenergic pathways were mainly ionic, while beta-adrenergic pathways were associated with the activation of uncoupling protein-1 (UCP1), which proved to be specifically present ...
Bone marrow adipose tissue (BMAT), sometimes referred to as marrow adipose tissue (MAT), is a type of fat deposit in bone marrow. It increases in states of low bone density, such as osteoporosis , [ 1 ] [ 2 ] anorexia nervosa / caloric restriction , [ 3 ] [ 4 ] skeletal unweighting such as that which occurs in space travel , [ 5 ] [ 6 ] and ...
Version of the hypothesis implicating failure to generate more adipocytes in tissue expandability. The adipose tissue expandability hypothesis posits that metabolic dysregulation that appears to be caused by excess weight, such as type 2 diabetes [1] and non-alcoholic fatty liver disease, [2] are triggered when an individual's capacity for storing excess calories in the subcutaneous adipose ...
Adipose tissue, commonly known as fat, [23] is a depository for energy in order to conserve metabolic homeostasis. As the body takes in energy in the form of glucose, some is expended, and the rest is stored as glycogen (primarily in the liver, muscle cells), or as triglyceride in adipose tissue. [24]