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Modified-release dosage is a mechanism that (in contrast to immediate-release dosage) delivers a drug with a delay after its administration (delayed-release dosage) or for a prolonged period of time (extended-release [ER, XR, XL] dosage) or to a specific target in the body (targeted-release dosage). [1] Sustained-release dosage forms are dosage ...
The General Instrument AY-3-8910 sound chip includes only a hold time parameter; the sustain level is not programmable. Another common variation in the same vein is the AHDSR (attack, hold, decay, sustain, release) envelope, in which the hold parameter controls how long the envelope stays at full volume before entering the decay phase. Multiple ...
Topical gels are commonly used as sustained release dosage forms. [5] [9] Usage of the sustained release dosage form reduces the administration of recurrent doses while maintaining serum dose levels at the therapeutic range (difference between toxic and therapeutic doses), hence improving patient compliance. [5]
Controlled or modified-release formulations alter the rate and timing at which a drug is liberated, in order to produce adequate or sustained drug concentrations. [28] The first controlled-release (CR) formulation that was developed was Dexedrine in the 1950s. [13]
In other sustained release formulations the matrix swells to form a gel through which the drug exits. Another method by which sustained release is achieved is through an osmotic controlled-release oral delivery system, where the active compound is encased in a water-permeable membrane with a laser drilled hole at one end. As water passes ...
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Image source: The Motley Fool. Comcast (NASDAQ: CMCSA) Q4 2024 Earnings Call Jan 30, 2025, 8:30 a.m. ET. Contents: Prepared Remarks. Questions and Answers. Call ...
ADSR envelope (attack–decay–sustain–release), a common type of music envelope; Accelerator-driven subcritical reactor, a nuclear reactor using a particle accelerator to generate a fission reaction in a sub-critical assembly of fissionable material; Attack Decay Sustain Release, the debut album from Simian Mobile Disco, released on 18 June ...