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The medial prefrontal cortex (mPFC) is composed of BA12, BA25, and anterior cingulate cortex: BA32, BA33, BA24. [1] Within that area is the dorsal nexus, which interconnects many parts of the brain. [19] The ventral prefrontal cortex is composed of areas BA11, BA13, and BA14. [1] (Also see the definition of the orbitofrontal cortex.)
The major change that occurs in the brain in adulthood is the constant myelination of neurons in the prefrontal cortex. [29] At age 20–29, executive functioning skills are at their peak, which allows people of this age to participate in some of the most challenging mental tasks.
The dorsomedial prefrontal cortex (dmPFC [1] [2] or DMPFC [3] [4] is a section of the prefrontal cortex in some species' brain anatomy. It includes portions of Brodmann areas BA8 , BA9 , BA10 , BA24 and BA32 , [ 5 ] although some authors identify it specifically with BA8 and BA9 .
The orbitofrontal cortex (OFC) is a prefrontal cortex region in the frontal lobes of the brain which is involved in the cognitive process of decision-making.In non-human primates it consists of the association cortex areas Brodmann area 11, 12 and 13; in humans it consists of Brodmann area 10, 11 and 47.
The ventromedial prefrontal cortex (vmPFC) is a part of the prefrontal cortex in the mammalian brain.The ventral medial prefrontal is located in the frontal lobe at the bottom of the cerebral hemispheres and is implicated in the processing of risk and fear, as it is critical in the regulation of amygdala activity in humans. [2]
The dorsolateral prefrontal cortex (DLPFC or DL-PFC) is an area in the prefrontal cortex of the primate brain. It is one of the most recently derived parts of the human brain. It undergoes a prolonged period of maturation which lasts into adulthood. [1] The DLPFC is not an anatomical structure, but rather a functional one.
The prefrontal cortex, being a central hub for executive functions, relies on the input from the mesocortical pathway to modulate and fine-tune cognitive processes essential for goal-directed behavior and decision-making. [20] Dysregulation of the neurons in this pathway has been connected to ADHD. [16]
The prefrontal cortex plays a significant role in mediating executive functions. [121] [123] [124] Planning involves activation of the dorsolateral prefrontal cortex (DLPFC), anterior cingulate cortex, angular prefrontal cortex, right prefrontal cortex, and supramarginal gyrus. [124]