Search results
Results From The WOW.Com Content Network
An osteoclast is a large multinucleated cell and human osteoclasts on bone typically have four nuclei [5] and are 150–200 μm in diameter. When osteoclast-inducing cytokines are used to convert macrophages to osteoclasts, very large cells that may reach 100 μm in diameter occur. These may have dozens of nuclei, and typically express major ...
When osteocytes were experimentally destroyed, the bones showed a significant increase in bone resorption, decreased bone formation, trabecular bone loss, and loss of response to unloading. [ 6 ] Osteocytes are mechanosensor cells that control the activity of osteoblasts and osteoclasts [ 16 ] within a basic multicellular unit (BMU), a ...
Bone remodeling is a process which maintains bone strength and ion homeostasis by replacing discrete parts of old bone with newly synthesized packets of proteinaceous matrix. [5] Bone is resorbed by osteoclasts, and is deposited by osteoblasts in a process called ossification. [6] Osteocyte activity plays a key role in this process. Conditions ...
Many believed osteoclasts and osteoblasts came from the same progenitor cell. Because of this, osteoclasts were thought to be derived from cells in connective tissue. Studies that observed that bone resorption could be restored by bone marrow and spleen transplants helped prove osteoclasts' hematopoietic origin. [3]
The a3 subunit is responsible in anchoring the vacuolar proton pump to the ruffled membrane of osteoclasts. [9] The V-ATPase is important in mediating the transport of hydrogen ions into the resorption lacunae , which is a pit on the bone surface enclosed by the osteoclast for bone resorption.
These cells are responsible for the general maintenance of the bone. A third type of bone cell found in flat bones is called an osteoclast, which destroys the bone using enzymes. There are three reasons that osteoclasts are normally used: the first is for the reparation of bones after a break.
Osteoclasts break down bone tissue, and along with osteoblasts and osteocytes form the structural components of bone. In the hollow within bones are many other cell types of the bone marrow . Components that are essential for osteoblast bone formation include mesenchymal stem cells (osteoblast precursor) and blood vessels that supply oxygen and ...
It contains the growth plate, the part of the bone that grows during childhood, and as it grows it ossifies near the diaphysis and the epiphyses. The metaphysis contains a diverse population of cells including mesenchymal stem cells , which give rise to bone and fat cells, as well as hematopoietic stem cells which give rise to a variety of ...