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Gestational (incidental) thrombocytopenia is a condition that commonly affects pregnant women.Thrombocytopenia is defined as the drop in platelet count from the normal range of 150,000–400,000/μL to a count lower than 150,000/μL. [1]
Unlike hemolytic disease of the fetus and newborn, NAIT occurs during the first pregnancy in up to 50% of cases, [1] and the affected fetuses may develop severe thrombocytopenia (<50,000 μL −1) very early during pregnancy (as early as 20 weeks gestation, consistent with the development of platelet antigens, [1] and the majority of the time ...
Hypercoagulability in pregnancy is the propensity of pregnant women to develop thrombosis (blood clots). Pregnancy itself is a factor of hypercoagulability (pregnancy-induced hypercoagulability), as a physiologically adaptive mechanism to prevent post partum bleeding . [ 1 ]
Similarities to other conditions, as well as normal pregnancy features, commonly lead to misdiagnosed cases or more often, delayed diagnosis. [ 6 ] [ 25 ] There is a general consensus regarding the main three diagnostic criteria of HELLP syndrome, which include hepatic dysfunction , thrombocytopenia and microangiopathic haemolytic anaemia in ...
Congenital amegakaryocytic thrombocytopenia (CAMT) is a rare autosomal recessive bone marrow failure syndrome characterized by severe thrombocytopenia, which can progress to aplastic anemia and leukemia. [4] CAMT usually manifests as thrombocytopenia in the initial month of life or in the fetal phase.
The Royal College of Obstetricians and Gynaecologists (RCOG) is a professional association based in London, United Kingdom. Its members, including people with and without medical degrees, work in the field of obstetrics and gynaecology , [ 1 ] that is, pregnancy , childbirth , and female sexual and reproductive health .
One common definition of thrombocytopenia requiring emergency treatment is a platelet count below 50,000/μL. [5] Thrombocytopenia can be contrasted with the conditions associated with an abnormally high level of platelets in the blood – thrombocythemia (when the cause is unknown), and thrombocytosis (when the cause is known). [6] [7]
The incidence of ITP in pregnancy is not well known. It may occur during any trimester of pregnancy. It is the most common cause of significant thrombocytopenia (platelets less than 100,000) in the second trimester, and it is a common cause of significant thrombocytopenia in the first and third trimesters. [63]