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Protein phosphatase 2 (PP2), also known as PP2A, is an enzyme that in humans is encoded by the PPP2CA gene. [ 2 ] [ 3 ] The PP2A heterotrimeric protein phosphatase is ubiquitously expressed, accounting for a large fraction of phosphatase activity in eukaryotic cells. [ 4 ]
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division.
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5518 51792 Ensembl ENSG00000105568 ENSMUSG00000007564 UniProt P30153 Q76MZ3 RefSeq (mRNA) NM_014225 NM_001363656 NM_016891 RefSeq (protein) NP_055040 NP_001350585 NP_055040.2 NP_058587 Location (UCSC) Chr 19: 52.19 – 52.23 Mb Chr 17: 21.17 – 21.19 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform is ...
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha is an enzyme that in humans is encoded by the PPP2R3A gene. [5] [6] Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division.
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The molecular mechanisms underlying JS are unknown. Broadly, PP2A dysfunction is known to be associated with other pathologies such as Alzheimer's disease, Parkinson's disease, and cancer. [6] Studies of specific JS-causing variants such as E420K have implicated PI3K/AKT/mTOR pathway dysregulation in JS pathogenesis. [4]
5516 19053 Ensembl ENSG00000104695 ENSMUSG00000009630 UniProt P62714 P62715 RefSeq (mRNA) NM_004156 NM_001009552 NM_017374 RefSeq (protein) NP_001009552 NP_059070 Location (UCSC) Chr 8: 30.77 – 30.81 Mb Chr 8: 34.09 – 34.11 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform is an enzyme that in humans is encoded ...