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There is no evidence to support the use of antipsychotics to treat the Lewy body dementias, [10] and they carry the additional risk of stroke when used in the elderly with dementia. [86] Medications (including tricyclic antidepressants and treatments for urinary incontinence) with anticholinergic properties that cross the blood–brain barrier ...
Recent studies have elicited neurochemical imbalances [24] resulting in autonomic hyperactivity and increase in dopamine levels in the victims. [3] Emergency personnel need to recognize these symptoms promptly to avoid the individual from spiraling into metabolic acidosis, rhabdomyolysis, multiorgan failure and ultimately death.
The loss of dopamine with age is thought to be responsible for many neurological symptoms that increase in frequency with age, such as decreased arm swing and increased rigidity. [41] Changes in dopamine levels may also cause age-related changes in cognitive flexibility .
For example, a study published in Neurology in 2021 found that high levels of cognitive activity, such as reading, playing games like checkers and puzzles, and writing letters, can delay the onset ...
Dopamine antagonists like antipsychotics or metoclopramide, which block dopamine receptors and thereby antagonize the dopaminergic effects of selegiline, could potentially reduce the effectiveness of the medication. [6] Dopamine-depleting agents like reserpine and tetrabenazine, by reducing dopamine levels, can also oppose the effectiveness of ...
Sundowning, or sundown syndrome, [1] is a neurological phenomenon wherein people with delirium or some form of dementia experience increased confusion and restlessness beginning in the late afternoon and early evening. It is most commonly associated with Alzheimer's disease but is also found in those