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A nociceptor (from Latin nocere 'to harm or hurt'; lit. ' pain receptor ') is a sensory neuron that responds to damaging or potentially damaging stimuli by sending "possible threat" signals [1] [2] [3] to the spinal cord and the brain.
This alteration of normal activity is explained by molecular and cellular changes of the primary afferent nociceptors in response to the nerve damage. [5] The abnormal activity of the damaged nerves is associated with the increased presence of mRNA for voltage-gated sodium channels. [14]
Type Aβ fibres, and type Aγ, are the type II afferent fibers from stretch receptors. [1] Type Aβ fibres from the skin are mostly dedicated to touch. However a small fraction of these fast fibres, termed "ultrafast nociceptors", also transmit pain. [6] Type Aδ fibers are the afferent fibers of nociceptors. Aδ fibers carry information from ...
Nociceptors have a certain threshold; that is, they require a minimum intensity of stimulation before they trigger a signal. Once this threshold is reached, a signal is passed along the axon of the neuron into the spinal cord. Nociceptive threshold testing deliberately applies a noxious stimulus to a human or animal subject to study pain.
External receptors that respond to stimuli from outside the body are called exteroreceptors. [4] Exteroreceptors include chemoreceptors such as olfactory receptors and taste receptors, photoreceptors (), thermoreceptors (temperature), nociceptors (), hair cells (hearing and balance), and a number of other different mechanoreceptors for touch and proprioception (stretch, distortion and stress).
Perl's return to the University of Utah in 1963 marked the beginning of a research interest in primary afferent neurons, which evolved into a focus on nociceptors. Paul Bessou visited Perl's laboratory and the two documented the activities of mechanoreceptive primary afferent neurons, whose thinly myelinated afferent fibers were responsive to ...
The primary afferent neurons responsible for histamine-induced itch are unmyelinated C-fibres. [1] Nociceptors. Two major classes of human C-fibre nociceptors exist: mechano-responsive nociceptors and mechano-insensitive nociceptors. Mechano-responsive nociceptors have been shown in studies to respond to mostly pain, and mechano-insensitive ...
A free nerve ending (FNE) or bare nerve ending, is an unspecialized, afferent nerve fiber sending its signal to a sensory neuron. Afferent in this case means bringing information from the body's periphery toward the brain. They function as cutaneous nociceptors and are essentially used by vertebrates to detect noxious stimuli that often result ...