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Around one in 100 people in the general US population is a carrier for type I Gaucher's disease, giving a prevalence of one in 40,000. [40] Among Ashkenazi Jews, the rate of carriers is considerably higher, at roughly one in 15. [40] Type II Gaucher's disease shows no particular preference for any ethnic group. [citation needed]
Gaucher's disease, in which lipids accumulate in inappropriate locations, occurs most frequently among Ashkenazi Jews; [22] the mutation is carried by roughly one in every 15 Ashkenazi Jews, compared to one in 100 of the general American population. [23] Gaucher's disease can cause brain damage and seizures, but these effects are not usually ...
In the United States, excess body weight is associated with the development of many types of cancer and is a factor in 14–20% of all cancer deaths. [34] Every year, nearly 85,000 new cancer diagnoses in the United States are related to obesity. [ 54 ]
Other risk factors include radiation therapy, chemotherapy, and organ transplantation. [1] Osteonecrosis is also associated with cancer, lupus, sickle cell disease, [11] HIV infection, Gaucher's disease, and Caisson disease (dysbaric osteonecrosis). [1] [12] Bisphosphonates are associated with osteonecrosis of the mandible (jawbone). [13]
The epidemiology of cancer is the study of the factors affecting cancer, as a way to infer possible trends and causes. The study of cancer epidemiology uses epidemiological methods to find the cause of cancer and to identify and develop improved treatments. This area of study must contend with problems of lead time bias and length time bias ...
For example, various Global Burden of Disease Studies investigate such factors and quantify recent developments – one such systematic analysis analyzed the (non)progress on cancer and its causes during the 2010–19-decade, indicating that 2019, ~44% of all cancer deaths – or ~4.5 M deaths or ~105 million lost disability-adjusted life years ...
Radiation exposure such as ultraviolet radiation and radioactive material is a risk factor for cancer. [72] [73] [74] Many non-melanoma skin cancers are due to ultraviolet radiation, mostly from sunlight. [73] Sources of ionizing radiation include medical imaging and radon gas. [73] Ionizing radiation is not a particularly strong mutagen. [75]
Sidransky's research includes both clinical and basic research aspects of Gaucher disease and Parkinson's disease, and her group first identified glucocerebrosidase as a risk factor for parkinsonism. She led two large international collaborative studies regarding the genetics of Parkinson's disease and dementia with Lewy bodies.