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CSF1R, the protein encoded by the CSF1R gene is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. CSF1R has 972 amino acids, is predicted to have a molecular weight of 107.984 kilo daltons , and is composed of an extracellular and a cytoplasmic domain .
Additionally, high levels of CSF-1 expression are observed in the endometrial epithelium of the pregnant uterus as well as high levels of its receptor CSF1R in the placental trophoblast. Studies have shown that activation of trophoblastic CSF1R by local high levels of CSF-1 is essential for normal embryonic implantation and placental development.
The CSF1 receptor protein primarily functions in regulation, survival, proliferation, and differentiation of microglial cells. [5] The mechanism of microglial dysfunction due to mutations in CSF1R to the myelin loss and axonal spheroid formation remains unknown. Further research is needed to better understand disease pathogenesis.
a cell-surface protein encoded, in humans, by the CSF1R gene. Also known as colony stimulating factor 1 receptor (CSF1R) and/or as macrophage colony-stimulating factor receptor (M-CSFR). It is a receptor, known to be expressed on monocytes and macrophages, for a cytokine called colony stimulating factor 1 (CSF1) and also interleukin 34 (IL34 ...
Emactuzumab is a humanized monoclonal antibody directed against the tyrosine kinase receptor colony stimulating factor 1 receptor (CSF1R; CSF-1R; CD115), also known as macrophage colony-stimulating factor receptor (M-CSFR), with potential antineoplastic and immunomodulating activities. Upon administration, emactuzumab binds to CSF1R expressed ...
The granulocyte-macrophage colony-stimulating factor receptor is a heterodimer composed of at least two different subunits; an α chain, and a β chain which is also present in the receptors for IL-3 and IL-5. The α subunit contains a binding site for granulocyte macrophage colony-stimulating factor, but associates with the ligand only with ...
This page was last edited on 17 December 2007, at 05:27 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may apply.
The granulocyte colony-stimulating factor receptor (G-CSF-R) also known as CD114 (Cluster of Differentiation 114) is a protein that in humans is encoded by the CSF3R gene. [5] G-CSF-R is a cell -surface receptor for the granulocyte colony-stimulating factor (G-CSF). [ 6 ]