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Within the year of 2014, the cost of prescriptions had increased by at least 11.4% and 58% within the last eight years. The average cost for a month supply of brand-name drugs can run up to a couple of hundred US dollars, whereas in Canada and Great Britain the same medication could cost up to $40 US dollars.
These rates, which are much higher than those seen in randomized clinical trials [75] have been the topic of extensive debate and discussion. [35] [87] Muscle pain and other symptoms often cause patients to stop taking a statin. [88] This is known as statin intolerance.
Once the compound entered pre-clinical development, process chemistry developed a cost-effective and scalable synthesis. [107] In atorvastatin's case, a key element of the overall synthesis was ensuring stereochemical purity in the final drug substance, and hence establishing the first stereocenter became a key aspect of the overall design.
Ezetimibe/atorvastatin (trade names Liptruzet, Atozet) is a cholesterol lowering combination drug. In the United States, it was approved in May 2013, by the Food and Drug Administration for the treatment of elevated low-density lipoprotein (LDL) in patients with primary or mixed hyperlipidemia as adjunctive therapy to diet. [ 1 ]
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MDCalc was founded by two emergency physicians, Graham Walker, MD, and Joseph Habboushe, MD, MBA, [5] and provides over 500 medical calculators and other clinical decision-support tools.