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Analgesic and behavioral effects were reported for 12 hours and plasma samples were analyzed for oxycodone metabolites for 48 hours. Grapefruit juice increased the mean area under the oxycodone concentration-time curve (AUC(0-∞)) by 1.7 fold, the peak plasma concentration by 1.5-fold and the half-life of oxycodone by 1.2-fold as compared to ...
A single glass of grapefruit juice can interfere with your body's ability to break down a medication. ... "Many food-drug interactions and potential side effects can be avoided by following ...
Important: If you're taking statins or medications for conditions like high blood pressure, cholesterol, heart arrhythmia, organ transplants, or allergies, it can be dangerous to eat grapefruit.
As with atorvastatin, simvastatin, and other statin drugs metabolized via CYP3A4, drinking grapefruit juice during lovastatin therapy may increase the risk of side effects. Components of grapefruit juice, the flavonoid naringin, or the furanocoumarin bergamottin inhibit CYP3A4 in vitro, [13] and may account for the in vivo effect of grapefruit ...
Furanocoumarins in grapefruit juice (i.e. bergamottin and dihydroxybergamottin) inhibit the cytochrome P450 enzyme CYP3A4, which is involved in the metabolism of most statins (however, it is a major inhibitor of only lovastatin, simvastatin, and to a lesser degree, atorvastatin) and some other medications [129] (flavonoids (i.e. naringin) were ...
Statins are effective and considered safe for most people, but they raise the risk of side effects, including muscle aches, liver problems, mental fuzziness and the potential for developing diabetes.
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