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Antibodies to HMG proteins are found in patients with autoimmune diseases. The SRY gene on the Y Chromosome, responsible for male sexual differentiation, contains an HMG-Box domain. A member of the HMG family of proteins, HMGB1 , has also been shown to have an extracellular activity as a chemokine , attracting neutrophils and mononuclear ...
HMGN proteins are part of broader group of proteins referred to as High Mobility group chromosomal (HMG) proteins. This larger group was named this for their high electrophoretic mobility in polyacrylamide gels and is differentiated into 3 distinct but related groups, one of them being HMGN proteins. [ 7 ]
The domain is most commonly found in the high mobility group (HMG) proteins, HMG14 and HMG17, however, it is also found in other proteins which bind to nucleosomes, e.g. NBP-45. NBP-45 is a nucleosomal binding protein, first identified in mice, [3] which is related to HMG14 and HMG17. NBP-45 binds specifically to nucleosome core particles, and ...
HMG-box containing proteins only bind non-B-type DNA conformations (kinked or unwound) with high affinity. [1]HMG-box domains are found in some high mobility group proteins, which are involved in the regulation of DNA-dependent processes such as transcription, replication, and DNA repair, all of which require changing the conformation of chromatin. [3]
HMGB1 has to interact with p53. [15] [16]HMGB1 is a nuclear protein that binds to DNA and acts as an architectural chromatin-binding factor. It can also be released from cells, an extracellular form in which it may bind to toll-like receptors (TLRs) or an inflammatory receptor called the receptor for advanced glycation end-products RAGE.
3151 n/a Ensembl ENSG00000198830 n/a UniProt P05204 n/a RefSeq (mRNA) NM_005517 n/a RefSeq (protein) NP_005508 n/a Location (UCSC) Chr 1: 26.47 – 26.48 Mb n/a PubMed search n/a Wikidata View/Edit Human Non-histone chromosomal protein HMG-17 is a protein that in humans is encoded by the HMGN2 gene. See also High mobility group protein HMG14 and HMG17 HMGN1 (HMG-14) References ^ a b c GRCh38 ...
High-mobility group protein B2 also known as high-mobility group protein 2 (HMG-2) is a protein that in humans is encoded by the HMGB2 gene. [5] [6] Function.
HMGA1 proteins have high amounts of diverse posttranslational modifications and are located mainly in the nucleus, especially in heterochromatin, but also in mitochondria and the cytoplasm. Recently it has been shown that HMGA1 proteins, HMGA1a and HMGA1b, can cross-link DNA fibers in vitro and can induce chromatin clustering in vivo suggesting ...