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Zafirlukast inhibits the action of CYP3A4, leading to drug-drug interactions with other drugs that are metabolized by CYP3A4. Genetic differences in LTC4 synthase and CYP2C9 may predict how a person reacts to zafirlukast treatment. Zafirlukast (brand name Accolate) was the first cysteinyl leukotriene receptor antagonist approved in the United ...
Zafirlukast was the first approved CysLT 1 receptor antagonist in the USA in September 26th 1996. [5] There are 2 other main medications that have been approved across the world, for example, montelukast which was approved February 2nd, 1996 [ 6 ] and pranlukast which was approved March 15th, 2007.
Related compounds include montelukast (Singulair) and zafirlukast (Accolate). These two compounds are leukotriene receptor antagonists which block the action of specific leukotrienes, while zileuton inhibits leukotriene formation. Research
Leukotriene receptor antagonists, including montelukast and zafirlukast, inhibit pro-inflammatory leukotrienes bindings to LTC4 and LTD4 receptors. This blocks the downstream inflammatory pathways that lead to bronchospasm and smooth muscle contractions in asthmatic patients.
An antileukotriene, also known as leukotriene modifier and leukotriene receptor antagonist, is a medication which functions as a leukotriene-related enzyme inhibitor (arachidonate 5-lipoxygenase) or leukotriene receptor antagonist (cysteinyl leukotriene receptors) and consequently opposes the function of these inflammatory mediators; leukotrienes are produced by the immune system and serve to ...
Cromolyn Nedocromil. Mast cell stabilizers are medications used to prevent or treat certain allergic disorders. They block mast cell degranulation, stabilizing the cell and thereby preventing the release of histamine and related mediators.
Accolate, also called zafirlukast, a chemical treatment for asthma; The Accolade (disambiguation) This page was last edited on 20 December 2024, at 04:07 (UTC) ...
Non-surgical methods of treating capsules include massage, external ultrasound, [9] treatment with leukotriene pathway inhibitors (e.g. Accolate, Singulair), [10] [11] and pulsed electromagnetic field therapy. [12] Image taken after a capsular contracture scar tissue removal surgery, showing the removed implant and removed tissue capsule [13]