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Drugs and drug candidates in this class are fungicidal against some yeasts (most species of Candida, but not Cryptococcus, Trichosporon, and Rhodotorula).Echinocandins also have displayed activity against Candida biofilms, especially in synergistic activity with amphotericin B and additive activity with fluconazole.
Anidulafungin [1]: 42 (trade names Eraxis, Ecalta) is a semisynthetic echinocandin used as an antifungal drug.It was previously known as LY303366. [3] [4] [5] It may also have application in treating invasive Aspergillus infection when used in combination with voriconazole. [6]
Caspofungin (INN; [1] [4] brand name Cancidas) is a lipopeptide antifungal drug from Merck & Co., Inc.. [5] It is a member of a class of antifungals termed the echinocandins. [medical citation needed] It works by inhibiting the enzyme (1→3)-β-D-glucan synthase and thereby disturbing the integrity of the fungal cell wall.
pentoxyfylline – xanthine derivative used in as an antiinflammatory drug and in the prevention of endotoxemia; pergolide – dopamine receptor agonist used for the treatment of pituitary pars intermedia dysfunction in horses; phenobarbital – anti-convulsant used for seizures; phenylbutazone – nonsteroidal anti-inflammatory drug (NSAID)
Echinocandin B, a lipopeptide, is a naturally occurring cyclic hexapeptide with a linoleoyl side chain. It belongs to a class of antifungal agents called echinocandins , which inhibits the synthesis of glucan, a major component of the fungal cell wall, via noncompetitive inhibition of a crucial enzyme , β-(1→3)- D -glucan synthase .
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