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Chemical structure of chloromethyl methyl ether (MOM-Cl) Chloroalkyl ethers are a class of organic compounds with the general structure R-O-(CH 2) n-Cl, characterized as an ether connected to a chloromethyl group via an alkane chain. Chloromethyl methyl ether (CMME) is an ether with the formula C H 3 OCH 2 Cl.
Chloromethyl methyl ether (CMME) is a compound with formula CH 3 OCH 2 Cl. A colorless liquid, it is a chloroalkyl ether.It is used as an alkylating agent.In organic synthesis, it is used for introducing the methoxymethyl ether (MOM) protecting group, [3] and is thus often called MOM-Cl or MOM chloride.
It is a kind of chloroalkyl ether and, like its congeners, often employed in organic synthesis to protect alcohols. They are usually derived from 2-methoxymethyl chloride. [1] [2] Closely related to MOM ethers are methoxyethoxymethoxy (MEM) protecting groups, introduced using 2-methoxyethoxymethyl chloride. The MEM protecting groups are more ...
The reagent can be prepared in two steps from triphenylphosphine.The first step is P-alkylation with chloromethyl methyl ether.. PPh 3 + CH 3 OCH 2 Cl → [CH 3 OCH 2 PPh 3]Cl. In the second step, the resulting phosphonium salt is deprotonated.
2-Methoxyethoxymethyl chloride is an organic compound with formula CH 3 OCH 2 CH 2 OCH 2 Cl. A colorless liquid, it is classified as a chloroalkyl ether. It is used as an alkylating agent. In organic synthesis, it is used for introducing the methoxyethoxy ether (MEM) protecting group. [2]
The Blanc chloromethylation (also called the Blanc reaction) is the chemical reaction of aromatic rings with formaldehyde and hydrogen chloride to form chloromethyl arenes. The reaction is catalyzed by Lewis acids such as zinc chloride. [1] The reaction was discovered by Gustave Louis Blanc (1872-1927) in 1923. [2] [3] Blanc chloromethylation
The mechanism of action is the insecticide binding at the GABA A site in the GABA-gated chloride channel (IRAC group 2A), which inhibits chloride flow into the nerve. [13]: 257 Other examples include dicofol, mirex, kepone, and pentachlorophenol. These can be either hydrophilic or hydrophobic, depending on their molecular structure. [14]
The acid chloride suffers attack by diazomethane with loss of HCl. The alpha-diazoketone (RC(O)CHN 2) product undergoes the metal-catalyzed Wolff rearrangement to form a ketene, which hydrates to the acid. [16] [17] [4] The rearrangement leaves untouched the stereochemistry at the carbon alpha to the acid chloride. [6]