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Their methods of transmission were not known. But Sappington developed a pill using quinine to treat the associated fevers. Beginning in 1832 he marketed these as "Dr. Sappington's Anti-Fever Pills," an early proprietary/patent medicine. Gradually he also instructed some of his relatives and salesmen to take the pills to prevent malaria.
Edwin Wiley Grove (December 27, 1850 – January 27, 1927), commonly known as E. W. Grove, was an American business magnate, entrepreneur, and self-made millionaire.He founded the Paris Medicine Company, creating and producing its most well-known patent medicine products, Grove's Tasteless Chill Tonic and Laxative Bromo Quinine tablets.
Quinine remained the antimalarial drug of choice until after World War II. Since then, other drugs that have fewer side effects, such as chloroquine, have largely replaced it. [71] Bromo Quinine were brand name cold tablets containing quinine, manufactured by Grove Laboratories. They were first marketed in 1889 and available until at least the ...
Cinchona bark was mainly important for the production of quinine, at that time just about the only effective remedy against malaria. The Kinabureau was part of a cartel of producers of cinchona bark and quinine. [2] About 90% of the cinchona bark was produced in the then Dutch East Indies, [3] mainly on the Pengalengan plateau near Bandung.
Hare experimented with quinine for treatment of malaria fevers. [7] Hare who had observed military action with the British forces in Afghanistan in 1839, used quinine to treat soldiers near the Nepal border. [7] In 1847, Hare published his findings in a pamphlet which caused a great sensation throughout the medical community in India.
There he perfected his method of cure. Though he shrouded his remedy in considerable mystery, and disguised its nature by mixing it with other drugs, the merit of his system lay in the fact that he administered the quinine in smaller quantities and at more frequent intervals than had been customary.