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Intravaginal administration is a route of administration where the substance is applied inside the vagina. Pharmacologically, it has the potential advantage to result in effects primarily in the vagina or nearby structures (such as the vaginal portion of cervix) with limited systemic adverse effects compared to other routes of administration ...
[15] [16] [17] The compound was being used as a vaginal antiseptic by the late 1800s. [18] Clinical studies of boric acid for treatment of vaginal infections began being published in the late 1900s and early 2000s. [5] Despite not being a pharmaceutical drug, boric acid is widely used by women in the management of vaginal infections.
This study focused on the drug as an 80 mg vaginal suppository, taken three times overnight by 10 women. [4] In another placebo-controlled, double blind study by Schmidt et al., the efficacy of different concentrations of terconazole creams were tested. Cream was applied for three days to 24 women between the ages of 18 and 60.
Vaginal insertion: Every act of intercourse: Spermicidal gel, suppository, or film [38] 21 (1 in 5) 16 (1 in 6.25) Spermicide: Vaginal insertion: Every act of intercourse: 1988 cervical cap and spermicide used by parous (discontinued in 2005) [note 5] Prentif: 32 (1 in 3) 26 (1 in 4) Barrier & spermicide: Vaginal insertion: Every act of intercourse
Vaginal infections Nystatin is also used to treat fungal infections in the vaginal area. It is commonly formulated into pessaries or vaginal cream for application. Ointments, gels, creams or dusting powder may be used when patients develop cutaneous lesions. Skin irritations may occur in some patients after applying the medication vaginally.
Pill and vaginal cream Vaginal cream for vaginal symptoms only; sourced from plants; estradiol is bioidentical until ingested and converted in the liver to estrone: Alora, Climara, Esclim, Estraderm, Vivelle and others Patch Sourced from plants Estrogel Transdermal gel Sourced from plants Estrasorb Topical cream Sourced from plants Estring
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Vaginal cornification grade is percentage cornification of vaginal epithelial cells and is 1 (+) = 10–25%, 2 (++) = 25–50%, and 3 (+++) = 50–75%. Mean change in vaginal smear test grade with different doses of estradiol pivalate (Estrotate) and estrone (Theelin-In-Oil) in oil solution by intramuscular injection in 10 to 20 women each.