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A case series of 147 patients showed that not all cases of acute digoxin overdose require anti‐digoxin Fab, nor should anti‐digoxin Fab dose be calculated based on ingested dose. In contrast, a higher mortality (7.6%) was noted in a case series of acute and chronic digoxin and digitoxin poisoning despite Fab being used first line.
Digoxin is usually given orally, but can also be given by IV injection in urgent situations (the IV injection should be slow, and heart rhythm should be monitored). While IV therapy may be better tolerated (less nausea), digoxin has a very long distribution half-life into the cardiac tissue, which will delay its onset of action by a number of ...
An unusual side effect of digoxin is a disturbance of color vision (mostly yellow and green) called xanthopsia. Vincent van Gogh's "Yellow Period" may have somehow been influenced by concurrent digitalis therapy. Other oculotoxic effects of digoxin include generalized blurry vision, as well as seeing a "halo" around each point of light.
Class IV agents affect calcium channels and the AV node. Class V agents work by other or unknown mechanisms. With regard to management of atrial fibrillation, classes I and III are used in rhythm control as medical cardioversion agents, while classes II and IV are used as rate-control agents.
It is an acetyl derivative of digoxin and an isomer of β-acetyldigoxin. α-Acetyldigoxin increases the contractility of the heart by its positive inotropic effect on cardiac muscle. [citation needed] The effects of α-acetyldigoxin begin 3–4 hours after administration, and maximize after 6–8 hours.
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V-Set: Multiple line IV injection site whereby several lines can be used at the same time for administering drugs to the patient.. In intravenous therapy a Y-Set, T-Set and V-Sets are Y-, T- and V-shaped three-way connector sets made of connecting plastic tubes used for delivering intravenous drugs into the body from multiple fluid sources.
The Biopharmaceutics Classification System (BCS) is a system to differentiate drugs on the basis of their solubility and permeability. [1]This system restricts the prediction using the parameters solubility and intestinal permeability.