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Flucytosine, also known as 5-fluorocytosine (5-FC), is an antifungal medication. [2] It is specifically used, together with amphotericin B, for serious Candida infections and cryptococcosis. [2] It may be used by itself or with other antifungals for chromomycosis. [2] Flucytosine is used by mouth and by injection into a vein. [2] [3]
Flucytosine (also known as 5-fluorocytosine, 5-FC, and Toca FC) is an antifungal drug. It is used in an extended-release formulation. Flucytosine is a prodrug of 5-fluorouracil (5-FU), a cancer drug. 5-Fluorouracil does not cross the blood–brain barrier well, but flucytosine does. [1]
Amphotericin B is an antifungal medication used for serious fungal infections and leishmaniasis. [3] The fungal infections it is used to treat include mucormycosis, aspergillosis, blastomycosis, candidiasis, coccidioidomycosis, and cryptococcosis. [4]
It was recommended in 2000 that cryptococcal meningitis be treated for two weeks with intravenous amphotericin B 0.7–1.0 mg/kg per day and oral flucytosine 100 mg/kg per day (or intravenous flucytosine 75 mg/kg per day [citation needed] day if the patient is unable to swallow), followed by oral fluconazole 400–800 mg daily for ten weeks [3 ...
Antifolates act primarily as inhibitors of both RNA and DNA, and are often grouped with nucleic acid inhibitors in textbooks. However, they also act indirectly as protein synthesis inhibitors (because tetrahydrofolate is also involved in the synthesis of amino acids serine and methionine), so they are sometimes considered as their own category, antimetabolites. [6]
Fungal meningitis, such as cryptococcal meningitis, is treated with long courses of high dose antifungals, such as amphotericin B and flucytosine. [ 55 ] [ 82 ] Raised intracranial pressure is common in fungal meningitis, and frequent (ideally daily) lumbar punctures to relieve the pressure are recommended, [ 55 ] or alternatively a lumbar drain.
Aspergillus felis is a heterothallic species of fungus in the genus Aspergillus which can cause aspergillosis in humans, dogs and cats. It was described for the first time in 2013 after being isolated from different hosts worldwide (North and South America, Europe, Africa, Northeast Asia, and Asia-Pacific).
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