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  2. Colchicine - Wikipedia

    en.wikipedia.org/wiki/Colchicine

    Colchicine was a narrow therapeutic index drug that was implicated in numerous death leading to the FDA forcefully removing injectable colchicine from the US Market. [ 63 ] [ 64 ] At this time oral colchicine was being used to treat gout attacks.

  3. Mitotic inhibitor - Wikipedia

    en.wikipedia.org/wiki/Mitotic_inhibitor

    While colchicine is not used to treat cancer in humans, it is commonly used to treat acute attacks of gout. [26] Colchicine is an anti-inflammatory drug that has been in continuous use for more than 3000 years. Colchicine is an oral drug, known to be used for treating acute gout and preventing acute attacks of familial Mediterranean fever (FMF).

  4. Pharmacodynamics - Wikipedia

    en.wikipedia.org/wiki/Pharmacodynamics

    Colchicine, a drug for gout, interferes with the function of the structural protein tubulin, while digitalis, a drug still used in heart failure, inhibits the activity of the carrier molecule, Na-K-ATPase pump. The widest class of drugs act as ligands that bind to receptors that determine cellular effects.

  5. List of drugs known for off-label use - Wikipedia

    en.wikipedia.org/wiki/List_of_drugs_known_for...

    Colchicine (Colcrys) for pericarditis: colchicine is indicated for the treatment and prevention of gout, though it is also generally considered first-line treatment for acute pericarditis, as well as preventing recurrent episodes. Although the exact mechanism of colchicine is not fully understood, its anti-inflammatory effect for pericarditis ...

  6. Polmacoxib - Wikipedia

    en.wikipedia.org/wiki/Polmacoxib

    Polmacoxib (trade name Acelex) is a nonsteroidal anti-inflammatory drug (NSAID) used to treat osteoarthritis. It was developed as CG100649 and approved for use in South Korea in February 2015. [ 1 ] It inhibits the enzymes carbonic anhydrase and COX-2 .

  7. Gout - Wikipedia

    en.wikipedia.org/wiki/Gout

    Colchicine is an alternative for those unable to tolerate NSAIDs. [20] At high doses, side effects (primarily gastrointestinal upset) limit its usage. [98] At lower doses, which are still effective, it is well tolerated. [39] [99] [96] [97] Colchicine may interact with other commonly prescribed drugs, such as atorvastatin and erythromycin ...

  8. File:Colchicine.svg - Wikipedia

    en.wikipedia.org/wiki/File:Colchicine.svg

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  9. Probenecid and colchicine - Wikipedia

    en.wikipedia.org/wiki/Probenecid_and_colchicine

    Probenecid with colchicine is a combination medication used to treat gout. Brand names include ColBenemid, Col-Probenecid, and Proben-C. [1] References