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Paget's disease of bone is the second most common metabolic bone disorder, after osteoporosis. [37] The overall prevalence and severity of Paget's disease are decreasing; the cause for these changes is unclear. [38] Paget's disease is rare in people less than 55 years of age, [7] and the prevalence increases with age. [38]
Paget's disease of the breast (also known as mammary Paget's disease) is a rare skin change at the nipple nearly always associated with underlying breast cancer. [2] Paget's disease of the breast was first described by Sir James Paget in 1874. [3] The condition is an uncommon disease accounting for 1 to 4% of all breast cancers cases.
Extramammary Paget's disease (EMPD) is a rare and slow-growing cancer, which occurs within the epithelial tissues [1] and accounts for 6.5% of all Paget's disease. [2] This disease presents similarly to the more conventional form of mammary Paget's disease (MPD). [ 3 ]
Paget's disease may refer to several conditions described by Sir James Paget, surgeon and pathologist: Paget's disease of bone (most common use of the term "Paget's disease") Paget's disease of the breast; Paget–Schroetter disease; Paget's abscess; Extramammary Paget's disease (EMPD)
James Paget in 1870 James Paget in 1881 "Surgery" Caricature by Spy published in Vanity Fair in 1876. Sir James Paget, 1st Baronet FRS HFRSE (11 January 1814 – 30 December 1899) (/ ˈ p æ dʒ ə t /, rhymes with "gadget") was an English surgeon and pathologist who is best remembered for naming Paget's disease [1] and who is considered, together with Rudolf Virchow, as one of the founders of ...
Leprosy, Paget's disease of bone Leonine facies is a facies that resembles that of a lion . It is seen in multiple conditions and has been classically described for lepromatous leprosy as well as Paget's disease of bone .
Multisystem proteinopathy (MSP) is a dominantly inherited, pleiotropic, degenerative disorder of humans that can affect muscle, bone, and/or the central nervous system.MSP can manifest clinically as classical amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), inclusion body myopathy (IBM), Paget's disease of bone (PDB), or as a combination of these disorders. [1]
Blade of grass sign (also known as flame sign [1]) is a radiologic sign referring to the lytic fronts seen in the leading edge of the long bone in Paget's disease. [2] It is usually seen as a wedge shaped area of radiolucency in the diaphysis of long bone. [1]