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Glimepiride is an antidiabetic medication within the sulfonylurea class, primarily prescribed for the management of type 2 diabetes. [ 1 ] [ 2 ] It is regarded as a second-line option compared to metformin , due to metformin's well-established safety and efficacy. [ 1 ]
Glipizide, sold under the brand name Glucotrol among others, is an anti-diabetic medication of the sulfonylurea class used to treat type 2 diabetes. [ 1 ] [ 2 ] It is used together with a diabetic diet and exercise.
Glyburide increases risk of hypoglycemia slightly more compared to glimepiride and glipizide; Metformin: Acts on the liver to reduce gluconeogenesis and causes a decrease in insulin resistance via increasing AMPK signalling. Associated with weight loss; Lower risk of hypoglycemia compared to other antidiabetics; Decreases low-density lipoprotein
They include glibenclamide (glyburide), glibornuride, gliclazide, glipizide, gliquidone, glisoxepide and glyclopyramide. Third-generation drugs: They include glimepiride, although it is sometimes considered a second-generation drug. [26] [27]
Pioglitazone/glimepiride, sold under the brand name Duetact among others, is a fixed-dose combination anti-diabetic medication for the treatment of type 2 diabetes ...
Hypoglycemia (11 - 12%) - while it was shown to have the same efficacy as glimepiride, one of the newer sulfonylureas, the European GUIDE study has shown that it has approximately 50% less hypoglycemic confirmed episodes in comparison with glimepiride. [14] Uncommon adverse effect between 1 - 10%: [13] Hypertension (3 - 4% incidence)
Berberine, a plant compound traditionally used in herbal medicine, is today commonly stocked on the shelves of health food stores and pharmacies as a supplement. Beyond weight loss, berberine also ...
Even though the drugs have a similar mechanism of action, there are subtle differences between acarbose and miglitol. Acarbose is an oligosaccharide, whereas miglitol resembles a monosaccharide. Miglitol is fairly well absorbed by the body, as opposed to acarbose.