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  2. Dacarbazine - Wikipedia

    en.wikipedia.org/wiki/Dacarbazine

    Common side effects include loss of appetite, vomiting, low white blood cell count, and low platelets. [3] Other serious side effects include liver problems and allergic reactions. [3] It is unclear if use in pregnancy is safe for the baby. [3] Dacarbazine is in the alkylating agent and purine analog families of medication. [3]

  3. MEK inhibitor - Wikipedia

    en.wikipedia.org/wiki/MEK_inhibitor

    Cobimetinib or XL518, approved by US FDA in Nov 2015 for use in combination with vemurafenib (Zelboraf(R)), for treatment of advanced melanoma with a BRAF V600E or V600K mutation. Selumetinib , had a phase 2 clinical trial for non-small cell lung cancer (NSCLC) which demonstrated an improvement in PFS, [ 5 ] and is now in phase III development ...

  4. Talimogene laherparepvec - Wikipedia

    en.wikipedia.org/wiki/Talimogene_laherparepvec

    Talimogene laherparepvec is delivered by injecting it directly into tumors, thereby creating a systemic anti-tumor immune response. [2]In the US, talimogene laherparepvec is FDA approved to treat Stage IIIb-IVM1c melanoma patients for whom surgical intervention is not appropriate and with tumors which can be directly injected; the EMA approved population in Europe is for Stage IIIb-IVM1a.

  5. Pembrolizumab - Wikipedia

    en.wikipedia.org/wiki/Pembrolizumab

    Micrograph showing a PD-L1 positive non-small cell lung carcinoma. PD-L1 immunostain. As of 2019, pembrolizumab is used via intravenous infusion to treat inoperable or metastatic melanoma, metastatic non-small cell lung cancer (NSCLC) in certain situations, as a first-line treatment for metastatic bladder cancer in patients who cannot receive cisplatin-based chemotherapy and have high levels ...

  6. Ipilimumab - Wikipedia

    en.wikipedia.org/wiki/Ipilimumab

    Ipilimumab, in combination with nivolumab, is indicated for the treatment of adults and adolescents twelve years and older with microsatellite instability-high or mismatch repair deficient metastatic colorectal cancer that has progressed following treatment with a fluoropyrimidine, oxaliplatin, and irinotecan.

  7. Cancer immunotherapy - Wikipedia

    en.wikipedia.org/wiki/Cancer_immunotherapy

    The US Food and Drug Administration (FDA) approved it in March 2017, for the treatment of Merkel-cell carcinoma, [85] an aggressive type of skin cancer. The EMA approved it in September 2017, for the same indication. [87] This is the first FDA-approved treatment for metastatic Merkel-cell carcinoma, a rare, aggressive form of skin cancer. [85]

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