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White sponge nevus (WSN) is an extremely rare autosomal dominant [4] condition of the oral mucosa (the mucous membrane lining of the mouth). It is caused by one or more mutations in genes coding for keratin, which causes a defect in the normal process of keratinization of the mucosa.
Parakeratosis is a mode of keratinization characterized by the retention of nuclei in the stratum corneum. [1] In mucous membranes, parakeratosis is normal. [2] In the skin, this process leads to the abnormal replacement of annular squames with nucleated cells.
Keratohyalin is a protein structure found in cytoplasmic granules of the keratinocytes in the stratum granulosum of the epidermis.Keratohyalin granules (KHG) mainly consist of keratin, profilaggrin, [1] loricrin [2] and trichohyalin proteins which contribute to cornification or keratinization, the process of the formation of epidermal cornified cell envelope.
Alveolar mucosa, the lining between the buccal and labial mucosae. It is a brighter red, smooth, and shiny with many blood vessels, and is not connected to underlying tissue by rete pegs. [6] Buccal mucosa, the inside lining of the cheeks; part of the lining mucosa. Labial mucosa, the inside lining of the lips; part of the lining mucosa. [7]
Keratosis (from kerat-+ -osis) [1] is a growth of keratin on the skin or on mucous membranes stemming from keratinocytes, the prominent cell type in the epidermis.More specifically, it can refer to:
Because of the differences between mucous membranes and the skin (e.g., keratinizing mucosa does not have a stratum lucidum and non keratinizing mucosa does not have this layer or normally a stratum corneum or a stratum granulosum), sometimes specialized texts give slightly different definitions of hyperkeratosis in the context of mucosae.
Keratinized epithelium has keratin deposited on the surface which makes it impermeable and dry. Examples of keratinized stratified squamous epithelium include skin, the epidermis of the palm of the hand, and the sole of the foot, [3] and the masticatory mucosa.
The degree of keratinization and the prominence of stippling appear to be related. [1] To be more specific, stippling occurs at sites of fusion of the epithelial ridges (also known as rete pegs – depression of epithelium) and correspond to the fusion of the valleys created by the connective tissue papillae (elevation of connective tissue ...