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Splenomegaly is an enlargement of the spleen. [1] The spleen usually lies in the left upper quadrant (LUQ) of the human abdomen.Splenomegaly is one of the four cardinal signs of hypersplenism which include: some reduction in number of circulating blood cells affecting granulocytes, erythrocytes or platelets in any combination; a compensatory proliferative response in the bone marrow; and the ...
A splenectomy is the surgical procedure that partially or completely removes the spleen.The spleen is an important organ in regard to immunological function due to its ability to efficiently destroy encapsulated bacteria.
There is no real treatment for Felty's syndrome, rather the best method in management of the disease is to control the underlying rheumatoid arthritis. Immunosuppressive therapy for RA often improves granulocytopenia and splenomegaly; this finding reflects the fact that Felty's syndrome is an immune-mediated disease.
It is a medical emergency and requires immediate treatment. Death has been reported to occur within 12 hours. [4] The spleen is necessary for protection against encapsulated bacteria (see Mechanism) and as such when removed by splenectomy it can lead to rapid unchallenged infection by encapsulated bacteria.
Even so, the disease is very rare and fewer than 500 occurrences of the disease have been reported as of 2005, [3] of which around 148 (including both children and adult cases) were documented to have been from between 1960 and 1992. [4] Less than 0.5% of all splenectomies, surgical removal of the spleen, are performed due to having this disorder.
Splenomegaly: Medical imaging: Largest dimension of over 11 cm, [27] [28] or craniocaudal height of 13 [29] cm. Moderate splenomegaly: the largest dimension is between 11–20 cm [27] Severe splenomegaly: the largest dimension is greater than 20 cm [27] Autopsy: Weight over upper limit of standard reference range, of 230 g (8.1 oz) [12] [13 ...
The spleen, in healthy adult humans, is approximately 7 to 14 centimetres (3 to 5 + 1 ⁄ 2 in) in length. An easy way to remember the anatomy of the spleen is the 1×3×5×7×9×10×11 rule. The spleen is 1 by 3 by 5 inches (3 by 8 by 13 cm), weighs approximately 7 oz (200 g), and lies between the ninth and eleventh ribs on the left-hand side ...
In young adults, the disease often results in fever, sore throat, enlarged lymph nodes in the neck, and fatigue. [2] Most people recover in two to four weeks; however, feeling tired may last for months. [2] The liver or spleen may also become swollen, [3] and in less than one percent of cases splenic rupture may occur. [6]