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Immunohistochemistry for pancreatic polypeptide in a mouse pancreas, 200×. Pancreatic polypeptide (PP) is a polypeptide secreted by PP cells in the endocrine pancreas.It is a hormone and it regulates pancreatic secretion activities, and also impacts liver glycogen storage and gastrointestinal secretion.
This is noted in human PP cells, but different animals have been shown to have different sized granules compared to humans, like rodents. In cats and dogs, PP cells have large granules. [6] In rats, PP cells have few granules, similar to humans. In dogs, some PP cells are located in the walls of the antrum of the stomach. [3] Pancreatic Islets
They give rise to both the endocrine and exocrine cells. Exocrine cells constitute the acinar cells and the ductal cells. The endocrine cells constitute the beta cells which make insulin, alpha cells which secrete glucagon, delta cells which secrete somatostatin and the PP-cells which secrete pancreatic polypeptide. [3]
Incretins are released after eating and augment the secretion of insulin released from pancreatic beta cells of the islets of Langerhans by a blood-glucose–dependent mechanism. [1] Some incretins also inhibit glucagon release from the alpha cells of the islets of Langerhans. In addition, they slow the rate of absorption of nutrients into the ...
APUD cells (DNES cells) constitute a group of apparently unrelated endocrine cells, which were named by the scientist A.G.E. Pearse, who developed the APUD concept in the 1960s based on calcitonin-secreting parafollicular C cells of dog thyroid. [1] These cells share the common function of secreting a low molecular weight polypeptide hormone ...
Illustration of a dog's pancreas. Cell-islet in the illustration refers to a pancreatic cell in the Islets of Langerhans, which contain insulin-producing beta cells and other endocrine related cells. Permanent damage to these beta cells results in Type 1, or insulin-dependent diabetes, for which exogenous insulin replacement therapy is the only ...