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Estradiol levels with 50 to 100 μg/day transdermal estradiol patches applied to the forearm and to the scrotum in a crossover study in 2 men with prostate cancer. [14] In 35 men treated continuously with one 100 μg/day estradiol patch scrotally, the mean estradiol level was ~500 pg/mL (range ~125–1,200 pg/mL). [14]
Target ranges for hormone levels in hormone therapy for transgender women; Source Place Estradiol, total Testosterone, total Refs Endocrine Society: United States: 100–200 pg/mL <50 ng/dL [1] World Professional Association for Transgender Health (WPATH) United States
[10] [15] During normal human pregnancy, estrogen production increases progressively and extremely high estrogen levels are attained. [19] Estradiol levels range from 1,000 to 40,000 pg/mL across pregnancy, [20] are on average 25,000 pg/mL at term, and reach levels as high as 75,000 pg/mL in some women. [21
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During the reproductive years of human females, levels of estradiol are somewhat higher than that of estrone, except during the early follicular phase of the menstrual cycle; thus, estradiol may be considered the predominant estrogen during human female reproductive years in terms of absolute serum levels and estrogenic activity.
In a normal adult female, the normal range of estrogen in the luteal phase (when ovulation happens, as well as the vascular tissue preparing for the potential zygote [3]) is 100 pg/ml, in comparison to the proliferative phase (when the uterine lining is thickening [4]) 40-250 pg/ml. [5]