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When used in the extemporaneous preparation of topical medications, it is supplied in the form of coal tar topical solution USP, which consists of a 20% w/v solution of coal tar in alcohol, with an additional 5% w/v of polysorbate 80 USP; this must then be diluted in an ointment base, such as petrolatum.
Seirogan (Japanese: 正露丸, formerly 征露丸) is a pharmaceutical drug marketed in Japan as a treatment for the digestive tract (especially as an antidiarrhoeal), whose main active ingredient is "wood creosote" (also wood-tar creosote, or beechwood creosote [1]).
The main active ingredient are phenols (26%), coal tar neutral oils (51%), soaps (13%) and water (10%) . The main toxicity of this product is that of phenols, which are non-specific cellular toxins causing damage to the gastrointestinal , hepatic , renal and neurological systems.
Tar made from coal or petroleum is considered toxic and carcinogenic because of its high benzene content, [citation needed] though coal tar in low concentrations is used as a topical medicine for conditions such as psoriasis. [11] [12] Coal and petroleum tar has a pungent odor. Coal tar is listed at number 1999 in the United Nations list of ...
Keratolytics include urea, salicylic acid, coal tar, lactic acid, pyrithione zinc and propylene glycol. [24] Coal tar shampoo formulations can be effective. [ 8 ] [ 24 ] Although no significant increased risk of cancer in human treatment with coal tar shampoos has been found, caution is advised since coal tar is carcinogenic in animals, and ...
-Citation needed for Coal tar. I would suggest this reference. PMID: 10773717, Comparative anti-dandruff efficacy between a tar and a non-tar shampoo. -The anti-androgen section is related to dandruff but not seborrheic dermatitis. It is questionable to include this. -There is no mention of anti-inflammatory agents such as tacrolimus.