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Medullary breast carcinoma is a rare type of breast cancer [1] that is characterized as a relatively circumscribed tumor [2] with pushing, rather than infiltrating, margins. It is histologically characterized as poorly differentiated cells with abundant cytoplasm and pleomorphic high grade vesicular nuclei. [ 3 ]
Medullary carcinoma may refer to one of several different tumors of epithelial origin. As the term "medulla" is a generic anatomic descriptor for the mid-layer of various organ tissues, a medullary tumor usually arises from the "mid-layer tissues" of the relevant organ. Medullary carcinoma most commonly refers to: Medullary thyroid cancer
Molecular classification of breast cancer from mRNA expression profiles. DNA microarrays have compared normal cells to breast cancer cells and found differences in the expression of hundreds of genes. Although the significance of many of those genetic differences is unknown, independent analyses by different research groups has found that ...
Comedocarcinoma is a kind of breast cancer that demonstrates comedonecrosis, which is the central necrosis [1] of cancer cells within involved ducts. Comedocarcinomas are usually non-infiltrating and intraductal tumors, characterized as a comedo-type, high-grade ductal carcinoma in situ (DCIS).
In addition, larger masses can stretch the overlying breast tissue leading to nipple retraction, chest wall fixation, and in advanced cases, ulceration from pressure necrosis. [ 6 ] Phyllodes tumors can grow to a variety of sizes, ranging from 0.8 to 40 cm, with the average tumor growing to between 4 and 8 cm. [ 7 ] Their growth can be slow ...
The basal-like carcinoma is a recently proposed subtype of breast cancer defined by its gene expression and protein expression profile. [ 1 ] Breast cancer can be divided into five molecular subtypes, including luminal subtype A, luminal subtype B, normal breast-like subtype, HER-2 overexpression subtype, and basal-like subtype. [ 2 ]
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