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However, excitatory interneurons using glutamate in the CNS also exist, as do interneurons releasing neuromodulators like acetylcholine. In addition to these general functions, interneurons in the insect CNS play a number of specific roles in different parts of the nervous system, and also are either excitatory or inhibitory.
CA3 has been implicated in a number of working theories on memory and hippocampal learning processes. Slow oscillatory rhythms (theta-band; 3–8 Hz) are cholinergically driven patterns that depend on coupling of interneurons and pyramidal cell axons via gap junctions, as well as glutaminergic (excitatory) and GABAergic (inhibitory) synapses.
The Golgi type II cells might be excitatory or inhibitory interneurons, or they can be both. Golgi type II cells function as inhibitory interneurons, which could produce response patterns that make the primary neurons more responsive to the beginning of stimuli and to temporal variations in the afferent input.
Gating can occur by shunting inhibition in which inhibitory interneurons change the membrane conductance of an excitatory target axon, thereby diffusing its excitatory signal. [2] A gating signal from the gatekeeper triggers these inhibitory interneurons in order to prevent one set of neurons from firing even when stimulated by another set.
This junction functions like a synapse. However, unlike most neurons, somatic efferent motor neurons innervate skeletal muscle, and are always excitatory. Visceral efferent neurons innervate smooth muscle, cardiac muscle, and glands, and have the ability to be either excitatory or inhibitory in function.
The two main neuronal classes in the cerebral cortex are excitatory projection neurons (around 70-80%) and inhibitory interneurons (around 20–30%). [2] Neurons are often grouped into a cluster known as a nucleus where they usually have roughly similar connections and functions. [3] Nuclei are connected to other nuclei by tracts of white matter.
Neuronal types in these classifications are split into excitatory, inhibitory and hundreds of corresponding sub-types. For example, pyramidal cells of layer 2-3 in human are classified as FREM3 type [ 16 ] and often have a high amount of Ih-current [ 19 ] generated by HCN-channel .
The hippocampus is a structure in the brain that has been associated with various memory functions. It is part of the limbic system , and lies next to the medial temporal lobe. It is made up of two structures, the Ammon's Horn , and the Dentate gyrus , each containing different types of cells .