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Benadryl containing diphenhydramine can interact with alcohol as both are central nervous system (CNS) depressants. Side effects such as drowsiness and dizziness may be enhanced when taking alcohol with diphenhydramine. [16] Mixing diphenhydramine with alcohol can also increase the chances of losing consciousness due to sedation. [17]
Some medications can also be dangerous with alcohol, Dr. Amanda Kahn, an internist and longevity medicine specialist in New York City, tells TODAY.com, including common drugs like Benadryl and GLP ...
The most prominent side effects are dizziness and sleepiness. [44] Diphenhydramine is a potent anticholinergic agent and potential deliriant in higher doses. This activity is responsible for the side effects of dry mouth and throat, increased heart rate, pupil dilation, urinary retention, constipation, and, at high doses, hallucinations or ...
Alcohol can exacerbate the symptoms and may directly contribute to increased severity of symptoms. The reasons for toxicity vary depending on the mixture of drugs. Usually, most victims die after using two or more drugs in combination that suppress breathing, and the low blood oxygen level causes brain death .
Medications like diuretics and antidepressants can increase the blood pressure-lowering effects of minoxidil. However, interactions are more likely with oral minoxidil than topical minoxidil.
Synthetic compounds such as diphenhydramine (Benadryl) and dimenhydrinate (Dramamine) are deliriants. Nutmeg, although purportedly not as strong or as unpleasant as diphenhydramine or scopolamine, is considered a deliriant, due to its propensity to cause anticholinergic-like symptoms when taken in large doses. [30]
Multiple teens have been hospitalized after ingesting up to 14 Benadryl doses at once, inspired by a TikTok challenge aimed at hallucinating. Experts say the activity could be deadly.
In July 1975, the J. B. Williams Co. began marketing Sominex 2. [37] On November 24, 1975, Attorney General Evelle J. Younger filed suit on behalf of the State of California against Williams Co., stating that the product did not warn against use by pregnant or nursing women or persons with asthma or COPD, nor did it notify consumers that it should not be used in conjunction with alcohol. [38]