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Unlike armodafinil ((R)-(–)-modafinil), esmodafinil has never been marketed on its own. [ 3 ] Esmodafinil is suspected to be less clinically useful for treating conditions that modafinil and armodafinil are marketed for, such as narcolepsy , shift work sleep disorder , and obstructive sleep apnea .
The cost of modafinil varied depending on factors such as location and insurance coverage; [218] [219] [220] still, in 2004, the price of modafinil in the US was around $120 or more per monthly supply. [218] However, the availability of generic versions has increased since then and may have driven down prices. [218] [219] [220]
Modafinil appeared to be more potent than adrafinil in animal studies, and was selected for further clinical development, with both adrafinil and modafinil eventually reaching the market. [18] Modafinil was first approved in France in 1994, and then in the United States in 1998. [19] Lafon was acquired by Cephalon in 2001. [20]
Flmodafinil (developmental code names CRL-40,940, NLS-4, JBG01-41), also known as bisfluoromodafinil and lauflumide, is a wakefulness-promoting agent related to modafinil which has been developed for treatment of a variety of different medical conditions.
Modafiendz, also known as N-methyl-4,4-difluoromodafinil or as N-methylbisfluoromodafinil, is a wakefulness-promoting agent related to modafinil that was never marketed. [1] [2] [3] It is sold online and used non-medically as a nootropic (cognitive enhancer).
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A Cephalon-founded study in which patients were administered modafinil, methylphenidate, and a placebo found that modafinil produces "psychoactive and euphoric effects and feelings consistent with [methylphenidate]." [12] Like modafinil, armodafinil is an inhibitor and/or inducer of certain cytochrome P450 enzymes.
The 26-year-old, whose real name is Litzy Lara Banuelos, entered the rehab center for her addiction to the dissociative anesthetic drug, which she was taking 5 to 6 grams of per day, her family ...