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The active ingredient in Kaopectate has changed since its original creation. Originally, kaolinite was used as the adsorbent and pectin as the emollient. Attapulgite (a type of absorbent clay) replaced the kaolinite in the 1980s, but was banned by the U.S. Food and Drug Administration in a ruling made in April 2003.
They were available over-the-counter without a prescription in many states until the early 1990s, at which time the FDA banned the sale of anti-diarrheal drugs containing kaolin and pectin; also, Donnagel-PG contained tincture of belladonna, which became prescription-only on January 1, 1993.
Pectin is composed of complex polysaccharides that are present in the primary cell walls of a plant, and are abundant in the green parts of terrestrial plants. [5] Pectin is the principal component of the middle lamella, where it binds cells. Pectin is deposited by exocytosis into the cell wall via vesicles produced in the Golgi apparatus. [6]
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Kaolinite (/ ˈ k eɪ. ə l ə ˌ n aɪ t,-l ɪ-/ KAY-ə-lə-nyte, -lih-; also called kaolin) [5] [6] [7] is a clay mineral, with the chemical composition Al 2 Si 2 O 5 4. It is a layered silicate mineral , with one tetrahedral sheet of silica ( SiO 4 ) linked through oxygen atoms to one octahedral sheet of alumina ( AlO 6 ).