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Monitoring diuresis: Diuresis can be monitored by weighing the person daily. The goal is weight loss of no more than 1.0 kg/day for people with both ascites and peripheral edema and no more than 0.5 kg/day for people with ascites alone. [19] If daily weights cannot be obtained, diuretics can also be guided by the urinary sodium concentration.
Supportive therapy for complications of cirrhosis include diuretics, albumin, vitamin K, blood products, antibiotics and nutritional therapy. Other patients may require surgery or a transplant. Transplant is required when the liver fails and there is no other alternative. [4]
Cirrhosis can take quite a long time to develop, and symptoms may be slow to emerge. [13] Some early symptoms include tiredness, weakness, loss of appetite, weight loss, and nausea. [13] Early signs may also include redness on the palms known as palmar erythema. [11] People may also feel discomfort in the right upper abdomen around the liver. [13]
Weight loss is the most effective treatment for MASLD and MASH. A loss of 5% to 10% body weight is recommended and has shown regression of liver damage, with 10% to 40% weight loss completely reversing MASH without cirrhosis. A weight loss of greater than 10% was associated with resolution of MASH in 90% of people in a biopsy based study.
That was followed by a 2022 recommendation from the U.S. Preventive Services Task Force (USPSTF) stressing that people ages 60 or older should not take a daily baby aspirin for heart health ...
For people with NAFLD or NASH, weight loss via a combination of diet and exercise was shown to improve or resolve the disease. [8] In more serious cases, medications that decrease insulin resistance, hyperlipidemia, and those that induce weight loss such as bariatric surgery as well as vitamin E have been shown to improve or resolve liver function.