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This may include weight loss, fever, headache, anxiety, trouble sleeping, arrhythmias, and heart failure. [2] Use in pregnancy and breastfeeding is generally safe. [3] [2] Liothyronine was approved for medical use in 1956. [2] It is available as a generic medication. [3]
Although manufacturer of Cytomel states half-life to be 2.5 days the half-life variability is great and can vary depending on the thyroid status of the patient. Newer studies have found the pharmakokinetics of T 3 to be complex and the half-life to vary between 10 – 22 hours.
Fasting in healthy, euthyroid people causes reduced T3 and elevated rT3, although TSH is usually unchanged. [3] [5] [10] Even moderate weight loss can lower T3. [2] This may be primarily via reduced levels of leptin (the satisfaction hormone). Low leptin levels can downregulate hypothalamic TRH neurons and cause a reduction in TSH.
Low levels of thyroid hormones can lead to symptoms including fatigue, weight gain, cold intolerance, dry, flakey skin, loss of hair and inability to concentrate.
The thyroid system of the thyroid hormones T 3 and T 4 [1] Thyroid hormones are two hormones produced and released by the thyroid gland, triiodothyronine (T 3) and thyroxine (T 4). They are tyrosine-based hormones that are primarily responsible for regulation of metabolism. T 3 and T 4 are partially composed of iodine, derived from food. [2]
GLP-1 drugs used for weight loss involve all kinds of side effects—good and not-so-good—that may or may not strike the average user. (Reminder that there are many of these meds now. GLP-1s ...
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