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Microsporidiosis is an opportunistic intestinal infection that causes diarrhea and wasting in immunocompromised individuals (HIV, for example). It results from different species of microsporidia , a group of microbial (unicellular) fungi.
The named species of microsporidia usually infect one host species or a group of closely related taxa. Approximately 10 percent of the known species are parasites of vertebrates — several species, most of which are opportunistic, can infect humans, in whom they can cause microsporidiosis.
Microsporidia is a group of fungi that infect species across the animal kingdom, one species of which can cause microsporidiosis in immunocompromised human hosts. [ 30 ] Pneumocystis jirovecii (formerly known as Pneumocystis carinii ) is a fungus that causes pneumocystis pneumonia , a respiratory infection.
Enterocytozoon bieneusi, commonly known as microsporidia, is a unicellular, obligate intracellular eukaryote.Their life cycle includes a proliferative merogonic stage, followed by a sporogonic stage resulting in small, environmentally resistant, infective spores, which is their transmission mode.
Fumagillin has been used in the treatment of microsporidiosis. [8] [9] It is also an amebicide.[10]Fumagillin can block blood vessel formation by binding to an enzyme methionine aminopeptidase 2 [11] and for this reason, the compound, together with semisynthetic derivatives, are investigated as an angiogenesis inhibitor [12] in the treatment of cancer.
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