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Haemophilia (British English), or hemophilia (American English) [6] (from Ancient Greek αἷμα (haîma) 'blood' and φιλία (philía) 'love of'), [7] is a mostly inherited genetic disorder that impairs the body's ability to make blood clots, a process needed to stop bleeding.
The prevalence of Hemophilia B in the population is about one in 40,000; Hemophilia B represents about 15% of patients with hemophilia. [6] Many female carriers of the disease have no symptoms. [6] However, an estimated 10-25% of female carriers have mild symptoms; in rare cases, female carriers may have moderate or severe symptoms. [6]
Haemophilia C (also known as plasma thromboplastin antecedent (PTA) deficiency or Rosenthal syndrome) is a mild form of haemophilia affecting both sexes, due to factor XI deficiency. [4] It predominantly occurs in Ashkenazi Jews. It is the fourth most common coagulation disorder after von Willebrand's disease and haemophilia A and B.
Joint capsule. Haemophilia A's phenotype has a quite wide range of symptoms encompassing both internal and external bleeding episodes. Individuals with more severe haemophilia tend to experience more intense and frequent bleeding, whereas those with mild haemophilia typically exhibit milder symptoms unless subjected to surgical procedures or significant trauma.
This page was last edited on 27 November 2020, at 02:15 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may apply.
Acquired haemophilia A (AHA) is a rare but potentially life-threatening bleeding disorder characterized by autoantibodies directed against coagulation factor VIII.These autoantibodies constitute the most common spontaneous inhibitor to any coagulation factor and may induce spontaneous bleeding in patients with no previous history of a bleeding disorder.
What is the difference between a mild hemophilia and von Willebrand disease (vWD)? Very small, apart from the underlying defect and the potential treatment. Hemophilia also causes a slightly different form of bleeding - it is more in muscles and joints. vWD, in contrast, affects the skin and mucous membranes. JFW | T@lk 21:13, 25 Apr 2005 (UTC)
Died at age 31, bleeding to death after a car accident. Infante Gonzalo (1914–1934). Died at age 19, bleeding to death after a car accident. Victoria Eugenie's two daughters, Infantas Beatriz (1909–2002) and Maria Cristina of Spain (1911–1996), both have living descendants none of whom has been known to have or to transmit haemophilia.