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Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that contains the pyrimidine base cytosine. The triphosphate group contains high-energy phosphoanhydride bonds, which liberate energy when hydrolized. DNA polymerase enzymes use this energy to incorporate deoxycytidine into a newly synthesized strand of DNA.
Deoxycytidine diphosphate is a nucleoside diphosphate. It is related to the common nucleic acid CTP, or cytidine triphosphate , with the -OH ( hydroxyl ) group on the 2' carbon on the nucleotide's pentose removed (hence the deoxy- part of the name), and with one fewer phosphoryl group than CTP .
Deoxycytidine is a deoxyribonucleoside, a component of deoxyribonucleic acid. It is similar to the ribonucleoside cytidine , but with one hydroxyl group removed from the C2' position. Deoxycytidine can be phosphorylated at C5' of the deoxyribose by deoxycytidine kinase , converting it to deoxycytidine monophosphate (dCMP), a DNA precursor.
In enzymology, a dCTP deaminase (EC 3.5.4.13) is an enzyme that catalyzes the chemical reaction dCTP + H 2 O ⇌ {\displaystyle \rightleftharpoons } dUTP + NH 3 Thus, the two substrates of this enzyme are dCTP and H 2 O , whereas its two products are dUTP and NH 3 .
In enzymology, a dCTP diphosphatase (EC 3.6.1.12) is an enzyme that catalyzes the chemical reaction dCTP + H 2 O ⇌ {\displaystyle \rightleftharpoons } dCMP + diphosphate Thus, the two substrates of this enzyme are dCTP and H 2 O , whereas its two products are dCMP and diphosphate .
66422 Ensembl ENSG00000179958 ENSMUSG00000042462 UniProt Q9H773 Q9QY93 RefSeq (mRNA) NM_024096 NM_023203 RefSeq (protein) NP_077001 NP_075692 Location (UCSC) Chr 16: 30.42 – 30.43 Mb Chr 7: 126.86 – 126.86 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse dCTP pyrophosphatase 1 is an enzyme that in humans is encoded by the DCTPP1 gene. See also Deoxycytidine triphosphate (dCTP ...
Cytidine triphosphate (CTP) is a pyrimidine nucleoside triphosphate.CTP, much like ATP, consists of a ribose sugar, and three phosphate groups.The major difference between the two molecules is the base used, which in CTP is cytosine.
"Deoxycytidine therapy in two patients with adenosine deaminase deficiency and severe immunodeficiency disease". Clinical Immunology and Immunopathology . 37 (1): 30– 36.