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Many metals, particularly heavy metals are toxic, but some are essential, and some, such as bismuth, have a low toxicity. Metals in an oxidation state abnormal to the body may also become toxic: chromium(III) is an essential trace element, but chromium(VI) is a carcinogen. Only soluble metal-containing compounds are toxic.
2,3-Dimercapto-1-propanesulfonic acid (abbreviated DMPS) and its sodium salt (known as Unithiol) are chelating agents that form complexes with various heavy metals. They are related to dimercaprol, which is another chelating agent. The synthesis of DMPS was first reported in 1956 by V. E. Petrunkin. [2]
Chelation challenge, also known as provocation testing, is used to indicate an elevated and mobilizable body burden of heavy metals including lead. [106] This testing involves collecting urine before and after administering a one-off dose of chelating agent to mobilize heavy metals into the urine. [106]
Foods such as rice, fish, fruits and vegetables have been known to contain varying amounts of metals. While heavy metals can be naturally excreted by the body through sweat and urine, if they are ...
Chelators can be used in chelation therapy to remove toxic metals in the body. TPEN is a chelator that has a high affinity for zinc. TPEN is a chelator that has a high affinity for zinc. For example, one study showed that TPEN is a stronger chelator compared to other chelators like pentetic acid (DTPA) when high levels of zinc are present (15 μM).
Ronholm said there isn't a Food and Drug Administration maximum standard for lead or cadmium, or other types of heavy metals, in foods, but it's something the agency is working on.