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16191 Ensembl ENSG00000113525 ENSMUSG00000036117 UniProt P05113 P04401 RefSeq (mRNA) NM_000879 NM_010558 RefSeq (protein) NP_000870 NP_034688 Location (UCSC) Chr 5: 132.54 – 132.56 Mb Chr 11: 53.61 – 53.62 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interleukin 5 (IL-5) is an interleukin produced by type-2 T helper cells and mast cells. Function Through binding to the ...
An inflammatory cytokine or proinflammatory cytokine is a type of signaling molecule (a cytokine) that is secreted from immune cells like helper T cells (T h) and macrophages, and certain other cell types that promote inflammation.
The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (T h 0 cells) to T h 2 cells. Upon activation by IL-4, T h 2 cells subsequently produce additional IL-4 in a positive feedback loop. IL-4 is produced primarily by mast cells, T h 2 cells, eosinophils and basophils. [4]
With an estimated 52.5 million adults in the U.S. affected by arthritis alone and up to 24% of adults experiencing muscle pain during their lifetime, effective topical pain relievers can be life ...
Nowadays, the blockade of IL-1 activity (especially IL-1β) is a standard therapy for patients with autoimmune diseases or lymphomas. Anakinra (IL-1Ra) is FDA-approved as a therapy for patients with rheumatoid arthritis, [54] because it reduces symptoms and slows joint destruction of this inflammatory disease.
A recombinant, slightly modified version of interleukin 1 receptor antagonist called anakinra is used in the treatment of rheumatoid arthritis, an autoimmune disease in which IL-1 plays a key role. [17] Anakinra differs from native human IL-1RA in that it has the addition of a single methionine residue at its amino terminus [18]