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Ciprofol (also known as cipepofol, or HSK3486) is a novel 2,6-disubstituted phenol derivative that is used for the intravenous induction of general anesthesia. [1] [2] A short-acting and highly selective γ-aminobutyric acid agonist, [3] ciprofol is 4–6 times more potent than other phenol derivatives such as propofol or fospropofol.
Propofol [7] is the active component of an intravenous anesthetic formulation used for induction and maintenance of general anesthesia. It is chemically termed 2,6-diisopropylphenol. It is chemically termed 2,6-diisopropylphenol.
Although it has a long terminal elimination half-life of 4 to 30 hours, plasma concentrations remain low after the typical induction dose. [ 33 ] Its advantages include “ antiemetic , antipruritic , bronchodilatory , and anticonvulsant properties”, [ 34 ] which makes it suitable for patients with kidney or liver insufficiency. [ 35 ]
Commonly used intravenous induction agents include propofol, sodium thiopental, etomidate, methohexital, and ketamine. Inhalational anaesthesia may be chosen when intravenous access is difficult to obtain (e.g., children), when difficulty maintaining the airway is anticipated, or when the patient prefers it.
The MAC is the percentage dose of anesthetic that will prevent a response to painful stimulus in 50% of subjects. The higher the MAC, generally, the less potent the anesthetic. Syringes prepared with medications that are expected to be used during an operation under general anesthesia maintained by sevoflurane gas: – Propofol, a hypnotic
Tools and Ingredients Needed. To properly clean your collard greens before cooking, you'll need: Large bowl or clean sink: For soaking the greens to remove excess dirt. Cutting board and sharp ...
Administration of induction agents followed by neuromuscular blockade agents helps to achieve optimal conditions for intubation. [8] Etomidate – It is an imidazole-derivative that stimulates GABA receptors. The dosage is between 0.2 and 0.6 mg/kg (commonly 20 to 50 mg doses). Dose reduction may be required in those with hypotension. [10]
(The Center Square) – A new report from California’s Legislative Analyst’s Office shows that the young adult mortality rate has remained much higher than pre-pandemic levels. “Overall ...